Under the guidance of the Internet of Things, the future smart home market has the opportunity to surpass smart phones, and smart lighting will follow the smart home boom and become an important market for LED lighting. In order to get rid of the price war, the LED lighting industry has been actively developing towards smart lighting in recent years. In the era of the Internet of Everything, lighting is no longer just a single product, but a system solution. Manufacturers try to enhance the added value of lighting equipment by integrating functions such as the Internet of Things and environmental sensing. International companies such as Philips, Osram, and local Chinese manufacturer Op Lighting have invested huge amounts of capital and R&D in intelligent lighting systems to lay out future markets. Smart lighting development trend (Source: Takuya Industry Research Institute, 2017/12) Under the guidance of the Internet of Things, the future smart home market has the opportunity to surpass smart phones, and smart lighting will follow the smart home boom and become an important market for LED lighting. In addition, buildings and cities are becoming smarter, and they also drive smart lighting technology and market growth. Building energy management systems (BEMS) and home energy management systems (HEMS) have integrated lighting into one, plus the introduction of semiconductor lighting. Speeding up the development of smart lighting. LEDInside predicts that in 2017, global smart lighting will enter a high-speed development stage with a market size of nearly US$4.6 billion and an annual growth rate of 95%. With the maturity of technology and products and the spread of related concepts, the market is expected to be 2020. The scale will reach 13.4 billion US dollars. Wisdom lighting has high profits, and global lighting manufacturers have stepped up their efforts. In recent years, lighting manufacturers have adopted different strategies to accelerate transformation and upgrading. They have successively abandoned general-purpose lighting with low profits, and switched to smart lighting with higher profits and better prospects. The following is a small series of The layout dynamics of major manufacturers: Philips Lighting In recent years, Philips Lighting has focused on the development of smart network lighting, promoting the development of the Internet of Things in the lighting industry under the premise of energy saving and environmental protection. Since its launch of Hue Smart Light Bulbs in 2012, Philips Hue, a subsidiary of its smart lighting brand, has launched a series of intelligent lighting products, including light strips, lamps, controllers and portable LED situation lights (Philips Hue Go) to meet different lighting needs. . Just control the lights on the iPad or iPhone via the Philips Hue App, or directly through the Apple iOS Smart Home System. In 2017, Philips has also deployed smart network lighting with a number of Chinese manufacturers. For example, in cooperation with Jingdong Mall's voice intelligent device "å®å’š ã€", users can control home lighting through the Chinese voice recognition of "å®å’š ã€". Osram Osram merged its smart lighting business (Lightfy) with the digital lighting business unit (Digital System) in 2016 to sell the traditional lighting business LEDVANCE and integrated resources to focus on industrial smart lighting. OSRAM Smart Home Lighting System (Source: Osram; Tuoba Industrial Research Institute, 2017/12) In 2017, OSRAM established the world's largest and most advanced LED chip production base in Kulim, Malaysia, including semiconductor LED chips based on 6-inch wafers. In addition, Osram's acquisition of a minority stake in Dutch software company Tvilight will help the brand further deepen its strength in intelligent lighting systems. Recently, OSRAM teamed up with Germany's Beckhoff and Microsoft project partners to launch a smart lighting solution for the Industrial 4.0 era, including innovative lighting, and a lighting management system that interconnects through the cloud and building automation. It has been applied in Beckhoff in Germany. "Future Factory". Op Lighting Since its inception in the lighting industry in 1996, Op Lighting has gradually transformed into a lighting system and a full range of home solutions service providers, with smart lighting as its core, and actively exploring smart home related applications. In addition, through the product development and cross-border cooperation, Op has realized the interconnection between lighting products and the remote control of smart terminals. For example, Opt and Huawei cross-border cooperation, launched a smart home product package at the end of 2016, and created a smart home sample house in projects such as COFCO Real Estate. Future Brand Planning will launch an upgraded version of Op Smart Home 2.0, which will develop more smart products in voice control, entertainment, health and safety applications. Easy to use, people-oriented for the future mainstream product trend Intelligent lighting products because of its system's high technical and strong correlation, the probability of problems is higher than traditional lighting, now more than 90% of smart home products are less convenient to install, after-sales The lack of maintenance is more normal. Under this circumstance, different manufacturers need to reduce the obstacles in product performance and increase the uniformity, thereby improving the convenience of consumers. In addition, in the initial stage of development, intelligent lighting is often caught in the blind pursuit of technology, the superposition of functions and the setting of hunting psychology, which leads consumers to be skeptical about smart products for a long time. As the development of smart lighting becomes more mature, the research on the wisdom of human experience will become the mainstream. Based on human behavior, visual effects and visual physiology and psychology research, the development of more scientific, human-oriented, intelligent, comfortable and healthy intelligent lighting is the main trend in the future. (
Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by synovial inflammation and hyperplasia, autoantibody production, cartilage damage and bone destruction, leading to co-morbidities. Despite a variety of therapeutic agents available for treatment, up to 40% of the patients do not respond to current therapies, including biological therapies. The etiology of the disease is mostly unknown; however, the role of JAK as a driver of immune-mediated conditions was discovered, leading to the use of JAK as therapeutic targets for rheumatoid arthritis. To reduce dose-related toxicity (as seen with some pan-JAK inhibitors) without significantly affecting efficacy, more selective JAK1 inhibitors, upadacitinib and [filgotinib], were developed. The FDA approved Upadacitinib in August 2019 for the treatment of adults with moderately to severely active rheumatoid arthritis who have had an inadequate response or intolerance to methotrexate. In December 2019, it was additionally approved by the European Commission for the same indication in patients with inadequate response or intolerance to one or more DMARDs and can be used as monotherapy or in combination with methotrexate. Upadacitinib is marketed under the brand name RINVOQâ„¢ for oral administration. It is currently being investigated in several clinical trials assessing its therapeutic effectiveness in other inflammatory diseases, such as psoriatic arthritis, ankylosing spondylitis, ulcerative colitis, and atopic dermatitis.
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